irretrievably (adverb)

1. The magic spell cast on the cursed prince irretrievably transformed him into a hideous creature.

2. The loss of the ancient library caused by the Great Fire of Alexandria irretrievably destroyed countless historical texts.

3. Pandora's decision to open the forbidden box irretrievably released all the evil powers into the world.

4. The irreversible decision to demolish the historical building irretrievably erased a significant piece of architectural heritage.